CKS-17

Names

[ Name ]:
CKS-17

[Synonym ]:
1067: PN: US20090175821 SEQID: 1339 claimed protein
CKS-17

Biological Activity

[Description]:

CKS-17 is a synthetic retroviral envelope peptide. CKS-17 has the highly conserved amino acid sequences occurring within the transmembrane envelope protein of many animal and human retroviruses. CKS-17 acts as an immunomodulatory epitope and exhibits suppressive properties for numerous immune functions[1][2][3].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

CKS-17 (THP-1 cells) induces increased intracellular cAMP via activation of adenylate cyclase[1]. CKS-17 (15 μM; EL4 cells) inhibits interleukin-2 production by tumor cell products[3].

[In Vivo]

CKS-17 (10 μM; i.d.; B6AF1 mice and C57BL/6J mice) inhibits delayed-type hypersensitivity (DTH) reactions to sheep erythrocytes in the feet of mice[2]. Animal Model: B6AF1 mice and C57BL/6J mice with DTH models[2] Dosage: 10 μM Administration: Intradermal injection, into the right hind footpad Result: Had a transient depressive effect on DTH reaction.

Chemical & Physical Properties

[ Density]:
1.41±0.1 g/cm3 (20 °C, 760 mmHg)

[ Molecular Formula ]:
C₈₇H₁₄₈N₂₆O₂₄

[ Molecular Weight ]:
1942.27000

[ Exact Mass ]:
1941.12000

[ PSA ]:
839.52000

[ LogP ]:
5.14200

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.