99273-04-8

99273-04-8 structure

Name: CKS-17
Chemical Name: L-Leucine, L-leucyl-L-glutaminyl-L-asparaginyl-L-arginyl-L-arginylglycyl-L-leucyl-L-α-aspartyl-L-leucyl-L-leucyl-L-phenylalanyl-L-leucyl-L-lysyl-L-α-glutamylglycylglycyl
CAS Number: 99273-04-8
Molecular Formula: C₈₇H₁₄₈N₂₆O₂₄
Molecular Weight: 1942.27000
Catalog: Research Areas Inflammation/Immunology
Create Date: 2016-05-15 02:43:44
Modify Date: 2024-01-02 16:26:42
CKS-17 is a synthetic retroviral envelope peptide. CKS-17 has the highly conserved amino acid sequences occurring within the transmembrane envelope protein of many animal and human retroviruses. CKS-17 acts as an immunomodulatory epitope and exhibits suppressive properties for numerous immune functions[1][2][3].

Name	L-Leucine, L-leucyl-L-glutaminyl-L-asparaginyl-L-arginyl-L-arginylglycyl-L-leucyl-L-α-aspartyl-L-leucyl-L-leucyl-L-phenylalanyl-L-leucyl-L-lysyl-L-α-glutamylglycylglycyl
Synonyms	1067: PN: US20090175821 SEQID: 1339 claimed protein CKS-17

Description	CKS-17 is a synthetic retroviral envelope peptide. CKS-17 has the highly conserved amino acid sequences occurring within the transmembrane envelope protein of many animal and human retroviruses. CKS-17 acts as an immunomodulatory epitope and exhibits suppressive properties for numerous immune functions[1][2][3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	CKS-17 (THP-1 cells) induces increased intracellular cAMP via activation of adenylate cyclase[1]. CKS-17 (15 μM; EL4 cells) inhibits interleukin-2 production by tumor cell products[3].
In Vivo	CKS-17 (10 μM; i.d.; B6AF1 mice and C57BL/6J mice) inhibits delayed-type hypersensitivity (DTH) reactions to sheep erythrocytes in the feet of mice[2]. Animal Model: B6AF1 mice and C57BL/6J mice with DTH models[2] Dosage: 10 μM Administration: Intradermal injection, into the right hind footpad Result: Had a transient depressive effect on DTH reaction.