9-(2-Deoxy-2-fluoro-D-arabinofuranosyl)hypoxanthine

Names

[ Name ]:
9-(2-Deoxy-2-fluoro-D-arabinofuranosyl)hypoxanthine

[Synonym ]:
9H-Fluorene,9-(2-cyclopropyl-2-propenylidene)
9-(2-cyclopropyl-2-propenylidene)fluorene

Biological Activity

[Description]:

2’-Deoxy-2’-fluoroarabino inosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
2.01

[ Boiling Point ]:
744.8ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₁FN₄O₄

[ Molecular Weight ]:
270.22

[ Exact Mass ]:
270.07600

[ PSA ]:
113.26000

[ Index of Refraction ]:
1.81

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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