Demecycline

Names

[ CAS No. ]:
987-02-0

[ Name ]:
Demecycline

[Synonym ]:
A IX
Demecycline
Demethyltetracycline
Demecyclinum
Demeciclina
Demecycline (USAN/INN)
6-Demethyltetracyclin

Biological Activity

[Description]:

Demecycline is the C6-demethylated derivative of Tetracycline (HY-A0107) against bacterial infections including pneumonia and other respiratory tract infections[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Yang W, Kong L, Wang Q, Deng Z, You D. Metabolic engineering of a methyltransferase for production of drug precursors demecycline and demeclocycline in Streptomyces aureofaciens. Synth Syst Biotechnol. 2020;5(3):121-130. Published 2020 Jun 23.

[2]. Results from the Swedish national screening programme 2005.

Chemical & Physical Properties

[ Density]:
1.69g/cm3

[ Boiling Point ]:
693.5ºC at 760mmHg

[ Molecular Formula ]:
C₂₁H₂₂N₂O₈

[ Molecular Weight ]:
430.40800

[ Flash Point ]:
373.2ºC

[ Exact Mass ]:
430.13800

[ PSA ]:
182.61000

[ LogP ]:
0.76120

[ Index of Refraction ]:
1.757