Aristolactam AIIIa

Names

[ Name ]:
Aristolactam AIIIa

[Synonym ]:
2,9-Dihydroxy-1-methoxydibenzo[cd,f]indol-4(5H)-one
Dibenz[cd,f]indol-4(5H)-one, 2,9-dihydroxy-1-methoxy-

Biological Activity

[Description]:

Aristolactam A IIIa (Sch 546909) is an aristolactam-type alkaloid that can be isolated from Glycosmis chlorosperma. Aristolactam A IIIa is a DYRK1A Inhibitor. Aristolactam A IIIa inhibits platelet aggregation induced by arachidonic acid (AA), collagen and platelet-activating factor (PAF). Aristolactam A IIIa has strong cytotoxic effect on HeLa cells[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK

[References]

[1]. Chia YC, et al. Aristolactams and dioxoaporphines from Fissistigma balansae and Fissistigma oldhamii. J Nat Prod. 2000 Aug;63(8):1160-3.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
521.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₁NO₄

[ Molecular Weight ]:
281.263

[ Flash Point ]:
268.9±30.1 °C

[ Exact Mass ]:
281.068817

[ PSA ]:
82.55000

[ LogP ]:
1.62

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.812

Related Compounds

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