BML-266

Names

[ Name ]:
BML-266

[Synonym ]:
1,4-Bis{[2-(4-hydroxyphenyl)ethyl]amino}-9,10-anthraquinone
9,10-Anthracenedione, 1,4-bis[[2-(4-hydroxyphenyl)ethyl]amino]-
1,4-bis{[2-(4-hydroxyphenyl)ethyl]amino}anthracene-9,10-dione
1,4-bis[(p-hydroxyphenethyl)amino]-anthraquinone
hms3261l04
1,4-di[(4-hydroxyphenethyl)amino]-9,10-dihydroanthracene-9,10-dione

Biological Activity

[Description]:

JFD00244 is a sirtuin 2 (SIRT2) inhibitor. Anti-tumor effect[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Sirtuin

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin

[References]

[1]. Ciarlo C, A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development. Elife. 2017 Aug 23;6. pii: e29145.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
780.2±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₀H₂₆N₂O₄

[ Molecular Weight ]:
478.538

[ Flash Point ]:
425.7±32.9 °C

[ Exact Mass ]:
478.189270

[ PSA ]:
98.66000

[ LogP ]:
4.45

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.733

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H400

[ Precautionary Statements ]:
P273

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ Hazard Codes ]:
N: Dangerous for the environment;

[ Risk Phrases ]:
50/53

[ Safety Phrases ]:
60-61

[ RIDADR ]:
UN 3077 9/PG 3

Articles

An in silico approach to discovering novel inhibitors of human sirtuin type 2.

J. Med. Chem. 47 , 6292-6298, (2004)

Type 2 human sirtuin (SIRT2) is a NAD(+)-dependent cytoplasmic protein that is colocalized with HDAC6 on microtubules. SIRT2 has been shown to deacetylate alpha-tubulin and to control mitotic exit in ...

Discovering inhibitors of human sirtuin type 2: novel structural scaffolds.

J. Med. Chem. 49 , 7239-7241, (2006)

A successful virtual screening experiment of novel SIRT2 inhibitors is described. Four out of 11 experimentally tested compounds showed in vitro inhibitory activity toward SIRT2 in a micromolar level,...

Related Compounds

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