ectoine

Names

[ Name ]:
ectoine

[Synonym ]:
ECTOINE
Pyrostatine B
(4S)-2-Methyl-1,4,5,6-tetrahydro-4-pyrimidinecarboxylic acid
4-Pyrimidinecarboxylic acid, 3,4,5,6-tetrahydro-2-methyl-, (4S)-
Ectoine sodium salt monohydrate
2-METHYL-1,4,5,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID
ectoine zwitterion
ECTOIN
MFCD03419286
RonaCare

Biological Activity

[Description]:

Ectoine is a natural cell protectant, an amino acid derivate produced by bacteria living under extremely harsh environmental conditions. Ectoine serves as an osmoregulatory compatible solute, increasing the hydration of the skin surface and stabilizing lipid layers, which is useful in skincare[1]. Ectoine demonstrates a good safety profile for the treatment of allergic rhinitis[2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

Bacterial[1]

[References]

[1]. Werkhäuser N, et al. Treatment of allergic rhinitis with ectoine containing nasal spray and eye drops in comparison with azelastine containing nasal spray and eye drops or with cromoglycic Acid containing nasal spray. J Allergy (Cairo). 2014;2014:176597.

[2]. Graf R, et al. The multifunctional role of ectoine as a natural cell protectant. Clin Dermatol. 2008 Jul-Aug;26(4):326-33.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
381.5±35.0 °C at 760 mmHg

[ Melting Point ]:
~280°

[ Molecular Formula ]:
C₆H₁₀N₂O₂

[ Molecular Weight ]:
142.156

[ Flash Point ]:
184.5±25.9 °C

[ Exact Mass ]:
142.074234

[ PSA ]:
61.69000

[ LogP ]:
0.27

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.597

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

Articles

Biophysical investigations of the structure and function of the tear fluid lipid layers and the effect of ectoine. Part B: artificial lipid films.

Biochim. Biophys. Acta 1838(10) , 2716-27, (2014)

The tear fluid lipid layer is present at the outermost part of the tear film which lines the ocular surface and functions to maintain the corneal surface moist by retarding evaporation. Instability in...

Biophysical investigations of the structure and function of the tear fluid lipid layer and the effect of ectoine. Part A: natural meibomian lipid films.

Biochim. Biophys. Acta 1838(10) , 2708-15, (2014)

The tear fluid lipid layer is the outermost part of the tear film on the ocular surface which protects the eye from inflammations and injuries. We investigated the influence of ectoine on the structur...

[Production and characterization of Methylomicrobium alcaliphilum 20Z knockout mutants, which has sucrose and ectoin synthesis defective genes].

Mikrobiologiia 82(2) , 251-3, (2013)