6-O-Methyldeoxyguanosine

Names

[ CAS No. ]:
964-21-6

[ Name ]:
6-O-Methyldeoxyguanosine

[Synonym ]:
O6-methyl-2'-deoxy-guanosine
2-Amino-6-methoxy-2'-deoxy-6-deaminoadenosine
6-O-METHYL-2'-DEOXYGUANOSINE
O(6)-methyl-2'-deoxyguanosine
O6-METHYL-2'-DEOXYGUANOSINE
O6-methyldeoxyguanosine

Biological Activity

[Description]:

O6-Methyldeoxy guanosine; DNA adduct is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.84 g/cm3

[ Boiling Point ]:
674.7ºC at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₅N₅O₄

[ Molecular Weight ]:
281.27

[ Flash Point ]:
361.9ºC

[ Exact Mass ]:
281.11200

[ PSA ]:
128.54000

[ Index of Refraction ]:
1.794

[ Storage condition ]:
2-8°C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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