Crisnatol

Names

[ Name ]:
Crisnatol

[Synonym ]:
2-((6-chrysenylmethyl)amino)-2-methyl-1,3-propanediol
Crisnatol [INN]
UNII-2J71UR51UE
1,3-Propanediol,2-((6-chrysenylmethyl)amino)-2-methyl
Crisnatolum [Latin]
CRISNATOL
Crisnatolum

Biological Activity

[Description]:

Crisnatol (BWA770U) is an orally active and anticancer agent, and a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol shows in vitro cytotoxicity against MCF-7 human breast cancer cells, breast cancer cell line (MDA-MB-231), but not normal human skin fibroblasts[1][2][3].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[In Vitro]

Crisnatol (1.3 μg/mL; 24, 48, 72 h) inhibits the replication of HepG2 cells, decreases cell viability by only 35%[2]. Crisnatol (0.05 μg/mL, 0.5 μg/mL; 1 μg/mL; 24 h; 37 ℃) drug metabolites chromatographic properties in both Hep G2 cells and human liver microsomes is similar to metabolites observed in extracts of feces from rats[2]. Cell Viability Assay[2] Cell Line: HepG2 cells Concentration: 1.3 μg/mL Incubation Time: 24 hours, 48 hours, 72 hours, and 126 hours Result: Inhibited cell viability at 48 hr.

[In Vivo]

Crisnatol (25 mg/kg; p.o.; single dose) shows oral activity and shows stable metabolite profile extract of rat feces by autoradiography[2].

Chemical & Physical Properties

[ Density]:
1.242g/cm3

[ Boiling Point ]:
620.9ºC at 760mmHg

[ Molecular Formula ]:
C₂₃H₂₃NO₂

[ Molecular Weight ]:
345.43400

[ Flash Point ]:
194.5ºC

[ Exact Mass ]:
345.17300

[ PSA ]:
52.49000

[ LogP ]:
4.37000

[ Index of Refraction ]:
1.72

Safety Information

[ HS Code ]:
2922199090

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

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