PM050489

Names

[ Name ]:
PM050489

Biological Activity

[Description]:

PM050489 is an effective polyketone inhibitor of Microtubule/Tubulin that can be isolated from Madagascan sponge Lithoplocamia lithistoides. PM050489 inhibits mitosis with an IC50 value of 26.4 nM. PM050489 has antitumor activity and can be used in cancer research[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin

Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[Target]

Mitosis[1]

[In Vitro]

PM050489 抑制 HT-29、A-549 和 MDA-MB-231 细胞的活力，GI50 分别为 0.46 nM、0.38 nM 和 0.45 nM[1]。 PM050489 (0.01 nM 和 0.1 nM；24 h) 破坏 A549 细胞中微管网络和有丝分裂纺锤体的形态[2]。 PM050489 (0.01、0.1、1 和 10 nM) 以剂量依赖性方式在 A549 细胞中抑制微管蛋白的聚合[2]。 Cell Cycle Analysis[2] Cell Line: A549 cells. Concentration: 0.25 nM. Incubation Time: 20 h. Result: Induced A549 cell cycle arrest in G2/M phase.

[References]

[1]. Martín MJ, et al. Isolation and first total synthesis of PM050489 and PM060184, two new marine anticancer compounds. J Am Chem Soc. 2013 Jul 10;135(27):10164-71.

[2]. Pera B, et al. New interfacial microtubule inhibitors of marine origin, PM050489/PM060184, with potent antitumor activity and a distinct mechanism. ACS Chem Biol. 2013 Sep 20;8(9):2084-94.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₁H₄₄ClN₃O₇

[ Molecular Weight ]:
606.15

Related Compounds

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