7-Hydroxyneolamellarin A

Names

[ Name ]:
7-Hydroxyneolamellarin A

Biological Activity

[Description]:

7-Hydroxyneolamellarin A is a natural product that could be derived from sponge Dendrilla nigra. 7-Hydroxyneolamellarin A is a potent hypoxia-inducible factor-1α (HIF-1α) inhibitor. 7-Hydroxyneolamellarin A attenuates the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibits vascular epidermal growth factor (VEGF) transcriptional activity. 7-Hydroxyneolamellarin A can be used in research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[In Vitro]

7-Hydroxyneolamellarin A (0-150 μM; 12 h; Hela 细胞, MCF-7 细胞和 4T1 细胞) 抑制 HIF-1 信号通路，具有低细胞毒性[1]。 7-Hydroxyneolamellarin A (0-100 μM; 12 h) 以剂量依赖性方式降低 Hela 细胞中 VEGF 的 mRNA 水平[1]。 7-hydroxyneolamellarin A (0-50 μM; 36 h) 抑制 Hela 细胞迁移、侵袭和增殖[1]。 Western Blot Analysis[1] Cell Line: Hela cells, MCF-7 cells and 4T1 cells Concentration: 0, 50, 100, and 150 μM Incubation Time: 12 hours Result: Decreased the HIF-1α protein levels in a dose-dependent manner.

[In Vivo]

7-Hydroxyneolamellarin A (15 mg/kg; i.v.; 具有 4T1 细胞异种移植物的 BALB/c 小鼠) 抑制体内肿瘤生长[1]。 Animal Model: BALB/c mice with 4T1 cells xenografts[1] Dosage: 15 mg/kg Administration: Intravenous injection; every 2 days for 16 days Result: Inhibited tumor growth in vivo.

[References]

[1]. Li G, et, al. Total synthesis and biological evaluation of 7-hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy. Bioorg Med Chem Lett. 2021 Oct 15;50:128338.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₁₉NO₅

[ Molecular Weight ]:
401.41

Related Compounds

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