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SB-633825

Names

[ CAS No. ]:
956613-01-7

[ Name ]:
SB-633825

Biological Activity

[Description]:

SB-633825 is a potent and ATP-competitive inhibitor of TIE2, LOK (STK10) and BRK with IC50s of 3.5 nM, 66 nM, 150 nM, respectively. SB-633825 can inhibit cancer cell growth and angiogenesis[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others

[Target]

IC50: 3.5 nM (TIE2), 66 nM (LOK) and 150 nM (BRK)[1]


[In Vitro]

SB-633825 inhibits TIE2 Tyrosine-protein kinase (TIE2), lymphocyte-oriented kinase (LOK; STK10) and breast tumor kinase (Brk; PTK6)[1]. SB-633825 inhibits LOK to 44% maximal activity and TIE2 to 75% maximal activity at 0.1 µM[1].

[References]

[1]. Elkins JM, et al. Comprehensive characterization of the Published Kinase Inhibitor Set. Nat Biotechnol. 2016 Jan;34(1):95-103.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H25N3O3S

[ Molecular Weight ]:
483.58

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds