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GUANOSINE 5'-DIPHOSPHORIC ACID DILITHIUM SALT

Names

[ CAS No. ]:
95648-84-3

[ Name ]:
GUANOSINE 5'-DIPHOSPHORIC ACID DILITHIUM SALT

[Synonym ]:
einecs 306-026-1

Biological Activity

[Description]:

Guanosine 5'-diphosphate-15N5 (GDP-15N5) dilithium is 15N labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. S Kajioka, et al. Guanosine diphosphate activates an adenosine 5'-triphosphate-sensitive K+ channel in the rabbit portal vein. J Physiol. 1991 Dec;444:397-418.  

[3]. Angmo S, et al. Identification of Guanosine 5'-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway. Sci Rep. 2017 Jan 5;7:40097.  

Chemical & Physical Properties

[ Molecular Formula ]:
C10H13Li2N5O11P2

[ Molecular Weight ]:
455.06700

[ Exact Mass ]:
455.04100

[ PSA ]:
278.11000


Related Compounds