Sulfiram

Names

[ CAS No. ]:
95-05-6

[ Name ]:
Sulfiram

[Synonym ]:
Kutka
tetraethylthiodicarbonic diamide ([[(C2H5)2N]C(S)]2S)
diethylcarbamothioyl N,N-diethylcarbamodithioate
Tetmos
Tetrucid
Sulfirame
Sulfiramum
Bis-(diaethyl-thiocarbamoyl)-sulfan
Sanigal
N1,N1,N3,N3-tetraethyl-1,2,3-trithiodicarbonic diamide
Tetmosol
bis (N,N-diethyl thiocarbamoyl)-sulphide
Bis-diaethylthiocarbamoyl-sulfid
SULFIRAM
tetraethylthiuram monosulfide
Sarcocide B

Biological Activity

[Description]:

Sulfiram, an ectoparasiticide, is a drug applied topically to treat scabies[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Parasite

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Mays DC, et al. Photolysis of sulfiram: a mechanism for its disulfiram-like reaction. Biochem Pharmacol. 1994 Nov 16;48(10):1917-25.

Chemical & Physical Properties

[ Density]:
1.139g/cm3

[ Boiling Point ]:
329.1ºC at 760mmHg

[ Molecular Formula ]:
C₁₀H₂₀N₂S₃

[ Molecular Weight ]:
264.47

[ Flash Point ]:
152.8ºC

[ Exact Mass ]:
264.07900

[ PSA ]:
95.96000

[ LogP ]:
2.97300

[ Index of Refraction ]:
1.59

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WQ1660000

CHEMICAL NAME :: Sulfide, bis(diethylthiocarbamoyl)

CAS REGISTRY NUMBER :: 95-05-6

BEILSTEIN REFERENCE NO. :: 1789060

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H20-N2-S3

MOLECULAR WEIGHT :: 264.50

WISWESSER LINE NOTATION :: 2N2&YUS&SYUS&N2&2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 8,329,1952

Safety Information

[ RIDADR ]:
UN 2811

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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