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Gypenoside XLIX

Names

[ CAS No. ]:
94987-08-3

[ Name ]:
Gypenoside XLIX

[Synonym ]:
(3β)-3-{[6-Deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)]-α-L-arabinopyranosyl]oxy}-20-hydroxy-19-oxodammar-24-en-21-yl β-D-glucopyranoside
Dammar-24-en-19-al, 3-[[O-6-deoxy-α-L-mannopyranosyl-(1-&gt;2)-O-[β-D-xylopyranosyl-(1->3)]-α-L-arabinopyranosyl]oxy]-21-(β-D-glucopyranosyloxy)-20-hydroxy-, (3β)-
Gypenoside XLIX

Biological Activity

[Description]:

Gypenoside XLIX, a dammarane-type glycoside, is a prominent component of G. pentaphyllum. Gypenoside XLIX is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator and inhibits cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) overexpression and hyperactivity in human endothelial cells[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR
Research Areas >> Inflammation/Immunology

[Target]

PPAR-α


[References]

[1]. Huang TH , et al. Gypenoside XLIX, a naturally occurring PPAR-alpha activator, inhibits cytokine-induced vascular cell adhesion molecule-1 expression and activity in human endothelial cells. Eur J Pharmacol. 2007 Jun 22;565(1-3):158-65.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
1105.1±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C52H86O21

[ Molecular Weight ]:
1047.227

[ Flash Point ]:
306.9±27.8 °C

[ Exact Mass ]:
1046.566162

[ PSA ]:
333.67000

[ LogP ]:
5.46

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.615

[ Storage condition ]:
2-8C

Related Compounds