Org 25935

Names

[ Name ]:
Org 25935

[Synonym ]:
Org 25935

Biological Activity

[Description]:

Org 25935 is a potent and selective glycine transporter 1 protein (GlyT1) inhibitor with an IC50 value of 100 nM. Org 25935 can decrease ethanol (EtOH) intake and EtOH preference in rats, whereas water intake is unaffected. Org 25935 can be used for researching alcohol dependence or abuse[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> GlyT

Signaling Pathways >> Neuronal Signaling >> GlyT

[Target]

GlyT1:100 nM (IC50)

[References]

[1]. Molander A, et al. The glycine reuptake inhibitor Org 25935 decreases ethanol intake and preference in male wistar rats. Alcohol Alcohol. 2007;42(1):11-18.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₆ClNO₃

[ Molecular Weight ]:
375.89

[ Exact Mass ]:
375.16000

[ PSA ]:
49.77000

[ LogP ]:
4.20790

Related Compounds

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