TRO 40303

Names

[ Name ]:
TRO 40303

[Synonym ]:
TRO-40303
7H-Benz[e]inden-7-one, 3-[(1R)-1,5-dimethylhexyl]dodecahydro-6-(3-hydroxypropyl)-3a,6-dimethyl-, oxime, (3R,3aR,5aS,6R,7E,9aS,9bS)-
3W389841RN
3-{(3R,3aR,5aS,6R,7E,9aS,9bS)-7-(Hydroxyimino)-3a,6-dimethyl-3-[(2R)-6-methyl-2-heptanyl]dodecahydro-1H-cyclopenta[a]naphthalen-6-yl}-1-propanol

Biological Activity

[Description]:

TRO 40303 is a novel cardioprotective compound that delays mitochondrial permeability transition pore (mPTP) opening, binds specifically to TSPO at the cholesterol site (Ki=150 nM); has no effect on the calcium retention capacity (CRC) of isolated mitochondria; causes significant reduction in reactive oxygen species production and subsequent calcium overload; reduces infarct size when administered before reperfusion in in vivo model.

[References]

References 1. Schaller S, et al. J Pharmacol Exp Ther. 2010 Jun;333(3):696-706. 2. Le Lamer S, et al. J Transl Med. 2014 Feb 7;12:38. 3. Hansson MJ, et al. Eur J Pharmacol. 2015 Aug 5;760:7-19. View Related Products by Target Mitochondrial Permeability Transition Pore (mPTP)

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
514.4±23.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₆H₄₇NO₂

[ Molecular Weight ]:
405.657

[ Flash Point ]:
344.4±11.9 °C

[ Exact Mass ]:
405.360687

[ LogP ]:
8.23

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.558

Related Compounds

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