Guanosine 5′-[γ-thio]triphosphate

Names

[ Name ]:
Guanosine 5′-[γ-thio]triphosphate

[Synonym ]:
EINECS 305-606-1
GTP|AS tetralithium salt
MFCD00135151
GTP-|A-S-Li4
Guanosine5'-(Trihydrogen Diphosphate) P'-Anhydride With Phosphorothioic Acid Lithiumsalt (1:4)
Guanosine 5′-[γ-thio]triphosphate
Gtp-Gamma-S Tetralithium Salt

Biological Activity

[Description]:

GTPγS (tetralithium) is a G-protein activator that protects proteins from proteolytic degradation, stimulates GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization. GTPγS (tetralithium) to couple with G- protein α, to study its effect on kinase activity. GTPγS (tetralithium) acts as a component of lysis buffer[1][2][3][4].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Julie G Hensler, et al. Differential Regulation of 5-HT1A Receptor-G Protein Interactions in Brain Following Chronic Antidepressant Administration. Neuropsychopharmacology. 2002 May;26(5):565-73.

[2]. Li-Bin Liu, et al. Insulin recruits GLUT4 from distinct compartments via distinct traffic pathways with differential microtubule dependence in rat adipocytes. J Biol Chem. 2003 Aug 8;278(32):30157-69. doi: 10.1074/jbc.M301511200.

[3]. Xufeng Wu, et al. Rab27a is an essential component of melanosome receptor for myosin Va. Mol Biol Cell. 2002 May;13(5):1735-49.

[4]. Pilar Sánchez-Blázquez, et al. Brain-specific Galphaz interacts with Src tyrosine kinase to regulate Mu-opioid receptor-NMDAR signaling pathway. Cell Signal. 2009 Sep;21(9):1444-54.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₂Li₄N₅O₁₃P₃S

[ Molecular Weight ]:
562.97800

[ Exact Mass ]:
563.00100

[ PSA ]:
354.87000

[ LogP ]:
0.76530

[ Storage condition ]:
20°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

Articles

Brain-specific Galphaz interacts with Src tyrosine kinase to regulate Mu-opioid receptor-NMDAR signaling pathway.

Cell Physiol. Biochem. 21 , 1444-54, (2009)

There is a certain cross-talk in the nervous system between N-methyl-D-aspartate receptors (NMDARs) and Mu-opioid receptors (MORs). While NMDARs participate in the desensitization of MORs, these in tu...

High-level production and characterization of a G-protein coupled receptor signaling complex.

FASEB J. 276 , 4515-28, (2009)

Elucidation of the molecular details of signal transduction through G-protein coupled receptors (GPCRs) awaits the solution of high-resolution structures of the receptor species involved in passing th...