2-Phenylindole

Names

[ CAS No. ]:
948-65-2

[ Name ]:
2-Phenylindole

[Synonym ]:
1H-Indole, 2-phenyl-
EINECS 213-436-3
MFCD00005608
2-Phenyl-1H-indole
A-PHENYLINDOL
2-phenyl-indol
a-Phenylindole
Indole,2-phenyl
2-pPhenyl-1H-indole
2-phenyl-1h-indol
2-Phenylindole
Stabilizer I
2-phenyl-indole

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
419.9±0.0 °C at 760 mmHg

[ Melting Point ]:
188-190 °C(lit.)

[ Molecular Formula ]:
C₁₄H₁₁N

[ Molecular Weight ]:
193.244

[ Flash Point ]:
176.6±11.9 °C

[ Exact Mass ]:
193.089142

[ PSA ]:
15.79000

[ LogP ]:
4.68

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.679

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM1272500

CHEMICAL NAME :: Indole, 2-phenyl-

CAS REGISTRY NUMBER :: 948-65-2

BEILSTEIN REFERENCE NO. :: 0132356

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C14-H11-N

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,44,1960

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H318-H335-H413

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R37/38;R41

[ Safety Phrases ]:
S26-S39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
NM1272500

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Melatonin-mediated Bim up-regulation and cyclooxygenase-2 (COX-2) down-regulation enhances tunicamycin-induced apoptosis in MDA-MB-231 cells.

J. Pineal Res. 58(3) , 310-20, (2015)

Melatonin is involved in many physiological functions, and it has differential effects on apoptosis in normal and cancer cells. However, the mechanism of its antitumor roles is not well understood. In...

The Drosophila MAPK p38c regulates oxidative stress and lipid homeostasis in the intestine.

PLoS Genet. 10(9) , e1004659, (2014)

The p38 mitogen-activated protein (MAP) kinase signaling cassette has been implicated in stress and immunity in evolutionarily diverse species. In response to a wide variety of physical, chemical and ...

Kuwanon V inhibits proliferation, promotes cell survival and increases neurogenesis of neural stem cells.

PLoS ONE 10(2) , e0118188, (2015)

Neural stem cells (NSCs) have the ability to proliferate and differentiate into neurons and glia. Regulation of NSC fate by small molecules is important for the generation of a certain type of cell. T...