Velagliflozin

Names

[ CAS No. ]:
946525-65-1

[ Name ]:
Velagliflozin

[Synonym ]:
velagliflozin
(1S)-1,5-Anhydro-1-[4-cyano-3-(4-cyclopropylbenzyl)phenyl]-D-glucitol
UNII:FV2YU8SL0P
D-Glucitol, 1,5-anhydro-1-C-[4-cyano-3-[(4-cyclopropylphenyl)methyl]phenyl]-, (1S)-

Biological Activity

[Description]:

Velagliflozin is an orally available sodium-glucose cotransporter 2 (SGLT2) inhibitor, with anti-diabetic activity.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> SGLT
Research Areas >> Metabolic Disease

[Target]

SGLT2[1]


[In Vitro]

Velagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, with anti-diabetic activity[1].

[In Vivo]

Velagliflozin (1 mg/kg, p.o.) increases cholesterol, albumin, beta-hydroxybutyrate (BHB), nonesterified fatty acids (NEFA), and urinary glucose excretion, and decreases respiratory exchange ratio in cats[1].

[References]

[1]. Hoenig M, et al. Effects of the sodium-glucose cotransporter 2 (SGLT2) inhibitor velagliflozin, a new drug with therapeutic potential to treat diabetes in cats. J Vet Pharmacol Ther. 2018 Apr;41(2):266-273.


[Related Small Molecules]

Phlorizin | Phloretin | LX-4211 | Ertugliflozin | Licogliflozin | Tofogliflozin (hydrate) | Bexagliflozin | Ipragliflozin

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
648.6±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H25NO5

[ Molecular Weight ]:
395.448

[ Flash Point ]:
346.1±31.5 °C

[ Exact Mass ]:
395.173279

[ LogP ]:
3.87

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.670

[ Storage condition ]:
-20°C

Related Compounds