Tomaymycin DM

Names

[ Name ]:
Tomaymycin DM

Biological Activity

[Description]:

Tomaymycin DM, a DNA alkylator, is a derivative of Tomaymycin, it is a PBD dimer, which is attached to tumor targeting antibodies to create antibody-drug conjugates (ADCs).

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin

[Target]

Pyrrolobenzodiazepines

[References]

[1]. Dr. Julia Mantaj, et al. From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody–Drug Conjugates (ADCs). Angew Chem Int Ed Engl. 2017 Jan 9; 56(2): 462–488.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₄N₂O₃

[ Molecular Weight ]:
258.27

Related Compounds

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