N3-C3-NHS ester

Names

[ CAS No. ]:
943858-70-6

[ Name ]:
N3-C3-NHS ester

[Synonym ]:
4-azidobutyrate-n-hydroxysuccinimide ester

Biological Activity

[Description]:

N3-C3-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

[Related Catalog]:

Research Areas >> Cancer

[Target]

Noncleavable

[References]

[1]. Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers. J Med Chem. 2017 Dec 14;60(23):9490-9507.

Chemical & Physical Properties

[ Molecular Formula ]:
C₈H₁₀N₄O₄

[ Molecular Weight ]:
226.18900

[ Exact Mass ]:
226.07000

[ PSA ]:
113.43000

[ LogP ]:
0.07476

Safety Information

[ HS Code ]:
2929909090

Customs

[ HS Code ]: 2929909090

[ Summary ]:
2929909090 other compounds with other nitrogen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%