N3-C4-NHS ester

Names

[ CAS No. ]:
478801-48-8

[ Name ]:
N3-C4-NHS ester

[Synonym ]:
succinimidyl azidovalerate
succinimidyl 5-azidovalerate
1-succinimidyl 5-azidopentanoate
5-azidopentanoic acid N-hydroxysuccinimide ester
5-azidovaleric acid N-succinimidyl ester
succinimidyl 5-azidopentanoate

Biological Activity

[Description]:

N3-C4-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

[Related Catalog]:

Research Areas >> Cancer

[Target]

Noncleavable


[References]

[1]. Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers. J Med Chem. 2017 Dec 14;60(23):9490-9507.

Chemical & Physical Properties

[ Molecular Formula ]:
C9H12N4O4

[ Molecular Weight ]:
240.21600

[ Exact Mass ]:
240.08600

[ PSA ]:
113.43000

[ LogP ]:
0.46486

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds