Propargyl-PEG2-Ms

Names

[ Name ]:
Propargyl-PEG2-Ms

[Synonym ]:
2-[2-(2-Propyn-1-yloxy)ethoxy]ethyl methanesulfonate
Ethanol, 2-[2-(2-propyn-1-yloxy)ethoxy]-, methanesulfonate

Biological Activity

[Description]:

Propargyl-PEG2-Ms is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Bai S, et al. Synthesis and structure-activity relationship studies of conformationally flexibletetrahydroisoquinolinyl triazole carboxamide and triazole substituted benzamide analogues as σ2 receptor ligands. J Med Chem. 2014 May 22;57(10):4239-51.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
358.0±27.0 °C at 760 mmHg

[ Molecular Formula ]:
C₈H₁₄O₅S

[ Molecular Weight ]:
222.259

[ Flash Point ]:
170.3±23.7 °C

[ Exact Mass ]:
222.056198

[ LogP ]:
-0.36

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.464

[ Storage condition ]:
2-8°C

Propargyl-PEG2-Ms

Names

Biological Activity

Chemical & Physical Properties

Related Compounds