Inarigivir soproxil

Names

[ Name ]:
Inarigivir soproxil

[Synonym ]:
inarigivir soproxil
[({[(2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-3-hydroxytetrahydro-2-furanyl]methoxy}{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl)-2-(hydroxymethyl)-4-methoxytetrahydro-3-furanyl]oxy}phosphoryl)sulfanyl]methyl isopropyl carbonate
365052M0DK

Biological Activity

[Description]:

Inarigivir soproxil is an agonist of innate immunity and shows potent antiviral activity against resistant hepatitis C virus (HCV) variants, with EC50s of 2.2 and 1.0 μM for HCV 1a/1b in cells of genotype 1 HCV replicon systems.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HCV

Research Areas >> Infection

[Target]

EC50: 2.2/1.0 μM (HCV 1a/1b)[1].

[In Vitro]

Inarigivir soproxil (SB 9200) is an oral modulator of innate immunity that is believed to act via the activation of the RIG-I and NOD2 pathways. SB 9200 has broad-spectrum antiviral activity against RNA viruses including hepatitis C virus (HCV), norovirus, respiratory syncytial virus and influenza and has demonstrated activity against hepatitis B virus (HBV). Inarigivir soproxil is shown to inhibit HCV replication and the range of inhibition is comparable between genotypes 1a and 1b. Inarigivir soproxil demonstrates pan-genotypic antiviral activity against HCV. Inarigivir soproxil is active against DAA-resistant HCV variants[1].

[References]

[1]. Jones M, ET AL. SB 9200, a novel agonist of innate immunity, shows potent antiviral activity against resistant HCV variants. J Med Virol. 2017 Sep;89(9):1620-1628.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Molecular Formula ]:
C₂₅H₃₄N₇O₁₃PS

[ Molecular Weight ]:
703.615

[ Exact Mass ]:
703.167297

[ LogP ]:
-0.66

[ Index of Refraction ]:
1.732

[ Storage condition ]:
2-8℃

Inarigivir soproxil

Names

Biological Activity

Chemical & Physical Properties

Related Compounds