Methyl 3-indolecarboxylate

Names

[ CAS No. ]:
942-24-5

[ Name ]:
Methyl 3-indolecarboxylate

[Synonym ]:
Methyl 1H-indole-3-carboxylate
Indole-3-carboxylic acid, methyl ester
1H-Indole-3-carboxylic acid, methyl ester
METHYL INDOLE-3-CARBOXYLATE
MFCD00189407

Biological Activity

[Description]:

Methyl indole-3-carboxylate is a natural product isolated from Sorangium cellulosum strain Soce895. Methyl indole-3-carboxylate shows a weak activity against the Gram-positive Nocardia sp with a MIC value of 33.33 μg/mL[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Rolf Jansen, et al. Nannozinones and sorazinones, unprecedented pyrazinones from myxobacteria. J Nat Prod. 2014 Nov 26;77(11):2545-52.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
331.7±15.0 °C at 760 mmHg

[ Melting Point ]:
149-152 °C(lit.)

[ Molecular Formula ]:
C₁₀H₉NO₂

[ Molecular Weight ]:
175.184

[ Flash Point ]:
154.4±20.4 °C

[ Exact Mass ]:
175.063324

[ PSA ]:
42.09000

[ LogP ]:
2.54

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.639

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Regioselective dibromination of methyl indole-3-carboxylate and application in the synthesis of 5,6-dibromoindoles.

Org. Biomol. Chem. 9(14) , 5021-3, (2011)

Treatment of methyl indole-3-carboxylate with bromine in acetic acid gives methyl 5,6-dibromoindole-3-carboxylate regioselectively, from which the parent 5,6-dibromoindole can be accessed via a one-po...

Nannozinones and sorazinones, unprecedented pyrazinones from myxobacteria.

J. Nat. Prod. 77(11) , 2545-52, (2014)

Nannozinones A (1) and B (2) were discovered as metabolites of the recently isolated Nannocystis pusilla strain MNa10913 belonging to the poorly studied myxobacterial family Nannocystaceae. In contras...

Methyl indole-3-carboxylate. Hu SC, et al.

Acta Crystallogr. Sect. E Struct. Rep. Online 61(6) , o1654-o1656, (2005)

Related Compounds

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