N-(DITHIOCARBAMOYL)-N-METHYL-D-GLUCAMINE, SODIUM SALT

N-methyl-N-dithiocarboxyglucamine (MDCG) mobilizes and promotes excretion of metallothione-bound 109Cd. N-methyl-N-dithiocarboxyglucamine shows effects on acute and chronic Cd intoxication[1].

Research Areas >> Inflammation/Immunology

N-methyl-N-dithiocarboxyglucamine (684-2736 mg/kg；腹腔注射，每日注射 3 次) 3 天内有效促进粪便镉排泄[1]。 N-methyl-N-dithiocarboxyglucamine (2736 mg/kg；腹腔注射，每周注射 3 次) 降低肾脏和肝脏的镉水平[1]。 Animal Model: Mice with CdCl2 injection[1] Dosage: 684, 1368 and 2736 mg/kg Administration: Intraperitoneal injection; 684, 1368 and 2736 mg/kg, three daily injection Result: Dose-dependently increased fecal Cd excretion and caused a fecal Cd excretion of almost 30% of the administered Cd over a 3-day period at a dose of 2736 mg/kg.

[1]. Gale GR, et al. Effects of sodium N-methyl-N-dithiocarboxyglucamine on cadmium distribution and excretion. Life Sci. 1984 Dec 17;35(25):2571-8.