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p53 and MDM2 proteins-interaction-inhibitor chiral

Names

[ CAS No. ]:
939981-37-0

[ Name ]:
p53 and MDM2 proteins-interaction-inhibitor chiral

[Synonym ]:
p53 and MDM2 proteins-interaction-inhibitor chiral
CS-0332
p53 and MDM2 proteins-interaction-inhibitor racemic
CS-0331
2-[4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-2-[4-(1,1-dimethylethyl)-2-ethoxyphenyl]-4,5-dihydro-4,5-dimethyl-1H-imidazol-1-yl]carbonyl]-1-piperazinyl]-1-(4-morpholinyl)ethanone

Biological Activity

[Description]:

p53 and MDM2 proteins-interaction-inhibitor (chiral) (Compound 32) is an inhibitor of the interaction between p53 and MDM2 proteins.

[Related Catalog]:

Signaling Pathways >> Apoptosis >> MDM-2/p53
Research Areas >> Cancer

[References]

[1]. Chen R, et al. A Fusion Protein of the p53 Transaction Domain and the p53-Binding Domain of the Oncoprotein MdmX as an Efficient System for High-Throughput Screening of MdmX Inhibitors. Biochemistry. 2017 Jun 27;56(25):3273-3282.


[Related Small Molecules]

Pifithrin-α hydrobromide | RG7388 | Nutlin-3a | AMG232 | Pifithrin-β (hydrobromide) | Stylomycin aminonucleoside | RG7112 | APR-246 | NVP-HDM201 | SAR 405838 | RITA (NSC 652287) | NVP-CGM097 | Tenovin-1 | SJ 172550

Chemical & Physical Properties

[ Density]:
1.24g/cm3

[ Boiling Point ]:
788.563ºC at 760 mmHg

[ Molecular Formula ]:
C40H49Cl2N5O4

[ Molecular Weight ]:
734.75400

[ Flash Point ]:
430.708ºC

[ Exact Mass ]:
733.31600

[ PSA ]:
77.92000

[ LogP ]:
6.36620

[ Storage condition ]:
2-8℃

Related Compounds