p53-MDM2-IN-1

Names

[ CAS No. ]:
381717-91-5

[ Name ]:
p53-MDM2-IN-1

[Synonym ]:
4-Benzoyl-5-(4-chlorophenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-1,5-dihydro-2H-pyrrol-2-one
MFCD01819429
2H-Pyrrol-2-one, 4-benzoyl-5-(4-chlorophenyl)-1,5-dihydro-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-

Biological Activity

[Description]:

p53-MDM2-IN-1 (Example 30) is an inhibitor of p53-MDM2/X protein interaction with an Ki value of 23.35 µM. p53-MDM2-IN-1 can be used for anti-tumor research[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Apoptosis >> MDM-2/p53
Signaling Pathways >> Metabolic Enzyme/Protease >> E1/E2/E3 Enzyme

[References]

[1]. Zhang W, et al. Pyrrylketone compound and application thereof as drug. China. CN102603717.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
686.1±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H20ClN3O3

[ Molecular Weight ]:
421.88

[ Flash Point ]:
368.7±31.5 °C

[ Exact Mass ]:
421.119324

[ LogP ]:
3.40

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.659

Related Compounds