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HO-PEG8-CH2CH2COOH

Names

[ CAS No. ]:
937188-60-8

[ Name ]:
HO-PEG8-CH2CH2COOH

[Synonym ]:
HO-PEG8-CH2CH2COOH
Alpha-hydroxy-ω-propionic acid octaethylene glycol

Biological Activity

[Description]:

HO-PEG8-CH2CH2COOH (Hydroxy-PEG8-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.148±0.06 g/cm3 (20 °C, 760 mmHg)

[ Boiling Point ]:
554.3±50.0 °C (760 mmHg)

[ Molecular Formula ]:
C19H38O11

[ Molecular Weight ]:
442.49800

[ Exact Mass ]:
442.24100

[ PSA ]:
131.37000

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds