OXA-01

Names

[ CAS No. ]:
936889-68-8

[ Name ]:
OXA-01

Biological Activity

[Description]:

OXA-01 is a potent mTORC1 and mTORC2 inhibitor, with IC50 values of 29 nM and 7 nM, respectively[1].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR

Research Areas >> Cancer

[In Vivo]

OXA-01 demonstrated broad anti-tumor activity in several different human xenograft models of various histologies. Furthermore, in GEO and Colo-205 colon xenograft models, OXA-01 demonstrated 100% TGI, whilst rapamycin treatment resulted in only 75% and 53% TGI, respectively[1].

[References]

[1]. OXA-01 displays improved anti-tumor activity in comparison to Rapamycin.

Chemical & Physical Properties

[ Density]:
1.61±0.1 g/cm3 (20 °C, 760 mmHg)

[ Molecular Formula ]:
C₂₁H₂₀ClN₅O₂

[ Molecular Weight ]:
409.86900

[ Exact Mass ]:
409.13100

[ PSA ]:
109.30000

[ LogP ]:
5.05280

Related Compounds

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