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POT-4

Names

[ CAS No. ]:
934461-40-2

[ Name ]:
POT-4

Biological Activity

[Description]:

POT-4 (AL-78898A), a Compstatin derivative, is a potent inhibitor of complement factor C3 activation. POT-4 can be used for age-related macular degeneration research[1][2]

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Complement System
Research Areas >> Metabolic Disease

[In Vitro]

A derivative of compstatin, a potent C3 inhibitor, POT-4 is a cyclic peptide that exhibits binding activity to C3, preventing cleavage to its active fragments C3a and C3b[2].

[References]

[1]. S. Kaushal, et al. Complement C3 inhibitor POT-4: Clinical Safety of Intravitreal Administration. ARVO Annual Meeting Abstract, 2009 Apr.

[2]. Robyn Troutbeck, et al. Therapeutic targeting of the complement system in age-related macular degeneration: a review. Clin Exp Ophthalmol. Jan-Feb 2012;40(1):18-26.

Chemical & Physical Properties

[ Molecular Formula ]:
C72H102N22O18S2

[ Molecular Weight ]:
1627.85

Related Compounds