TBCA

Names

[ Name ]:
TBCA

[Synonym ]:
(2E)-3-(2,3,4,5-tetrabromophenyl)prop-2-enoic acid
tetrabromocinnamic acid
2-Propenoic acid, 3-(2,3,4,5-tetrabromophenyl)-, (2E)-
(2E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid

Biological Activity

[Description]:

TBCA is a highly selective CK2 (casein kinase II) inhibitor with an IC50 of 110 nM and a Ki of 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Casein Kinase

Signaling Pathways >> Stem Cell/Wnt >> Casein Kinase

[Target]

CK2:110 nM (IC50)

CK2:77 nM (Ki)

[In Vitro]

TBCA (0-100 μM; 24 hours) shows a drastic effect on Jurkat cells viability[1]. TBCA also inhibits CK2 double mutant (Val66 Ile174) with an IC50 of 0.68 μM[1]. TBCA dose-dependently inhibits platelet aggregation and secretion induced by various agonists including 2-MeSADP, AYPGKF, SFLLRN, and CRP. TBCA also inhibits phosphorylation of PDK1, Akt, and GSK3β induced by AYPGKF[2]. Cell Viability Assay[1] Cell Line: Jurkat cells Concentration: 0-100 μM Incubation Time: 24 hours Result: The viability of Jurkat cells was reduced.

[References]

[1]. Pagano MA, et al. Tetrabromocinnamic acid (TBCA) and related compounds represent a new class of specific protein kinase CK2 inhibitors. Chembiochem. 2007;8(1):129-139.

[2]. Ryu SY, Kim S. Evaluation of CK2 inhibitor (E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid (TBCA) in regulation of platelet function. Eur J Pharmacol. 2013;720(1-3):391-400.

Chemical & Physical Properties

[ Density]:
2.4±0.1 g/cm3

[ Boiling Point ]:
490.8±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₄Br₄O₂

[ Molecular Weight ]:
463.743

[ Flash Point ]:
250.6±28.7 °C

[ Exact Mass ]:
459.694458

[ PSA ]:
37.30000

[ LogP ]:
5.28

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.714

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Statements ]:
H413

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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