2-Aminobenzimidazole
Names
[ CAS No. ]:
934-32-7
[ Name ]:
2-Aminobenzimidazole
[Synonym ]:
usafek-4037
2H-Benzimidazol-2-imine, 1,3-dihydro-
2-aMinobenziMidazde
2-BENZIMIDAZOLAMINE
1,3-Dihydro-2H-benzimidazol-2-imine
UNII-E65DE7521V
2-amino-1H-benzimidazole
MFCD00005596
2-amino-benzimidazol
2-Aminobenzimidazole
EINECS 213-280-6
2-amino-benzimidazole
BenziMidazoloniMide
1H-Benzimidazol-2-amine
benzimidazole-amine
2-BENZIMIDAZOLYLAMINE
AMINO-2-BENZIMIDAZOLE
2-Iminobenzimidazoline
Rabeprazole Impurity 19
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
368.9±25.0 °C at 760 mmHg
[ Melting Point ]:
226-230 °C(lit.)
[ Molecular Formula ]:
C7H7N3
[ Molecular Weight ]:
133.151
[ Flash Point ]:
204.6±10.4 °C
[ Exact Mass ]:
133.063995
[ PSA ]:
54.70000
[ LogP ]:
0.78
[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C
[ Index of Refraction ]:
1.780
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DD5775000
- CHEMICAL NAME :
- Benzimidazole, 2-amino-
- CAS REGISTRY NUMBER :
- 934-32-7
- BEILSTEIN REFERENCE NO. :
- 0116525
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C7-H7-N3
- MOLECULAR WEIGHT :
- 133.17
- WISWESSER LINE NOTATION :
- T56 BM DNJ CZ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD40 - Lethal Dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 126 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 426 mg/kg
- SEX/DURATION :
- female 8-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
MUTATION DATA
- TYPE OF TEST :
- DNA repair
- TEST SYSTEM :
- Bacteria - Escherichia coli
- DOSE/DURATION :
- 2 mg/disc
- REFERENCE :
- JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.B11- 1976- Volume(issue)/page/year: 21,319,1986
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H315-H317-H319-H335
[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R22;R36/37/38
[ Safety Phrases ]:
S26-S36/37/39-S22
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
DD5775000
[ HS Code ]:
29339990
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
ChemPhysChem 12(9) , 1747-55, (2011)
An investigation of 2-aminobenzimidazole was carried out by calculations at HF, MP2, and DFT levels of theory and also by UV and IR spectroscopy. The quantum chemical calculations predict a full shift...
Brain-penetrating 2-aminobenzimidazole H(1)-antihistamines for the treatment of insomnia.Bioorg. Med. Chem. Lett. 19(15) , 4380-4, (2009)
The benzimidazole core of the selective non-brain-penetrating H(1)-antihistamine mizolastine was used to identify a series of brain-penetrating H(1)-antihistamines for the potential treatment of insom...
Chemical biology strategy reveals pathway-selective inhibitor of NF-kappaB activation induced by protein kinase C.ACS Chem. Biol. 5 , 287-299, (2010)
Dysregulation of NF-kappaB activity contributes to many autoimmune and inflammatory diseases. At least nine pathways for NF-kappaB activation have been identified, most of which converge on the Ikappa...