N-Methyl-2-pyrrolidone-d3

Names

[ CAS No. ]:
933-86-8

[ Name ]:
N-Methyl-2-pyrrolidone-d3

[Synonym ]:
Pharmasolve-d3
N-Methylpyrrolidone-d3
N-Trideuteriomethyl-2-pyrrolidon
M-Pyrol-d3
NMP-d3
1-Methylpyrrolidone-d3
N-Methyl-|A-butyrolactam-d3
Microposit 2001-d3
AgsolEx 1-d3
Pyrol M-d3
N-Methylbutyrolactam-d3

Biological Activity

[Description]:

N-Methyl-2-pyrrolidone-d3 is the deuterium labeled N-Methylpyrrolidone[1]. N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an organic polar solvent. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals[2][3].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Jing Wang, et al. Nitrate stimulation of N-Methylpyrrolidone biodegradation by Paracoccus pantotrophus: Metabolite mechanism and Genomic characterization. Bioresour Technol. 2019 Dec;294:122185.  

[3]. Claudia Julieta Solís-González, et al. Novel Metabolic Pathway for N-Methylpyrrolidone Degradation in Alicycliphilus sp. Strain BQ1. Appl Environ Microbiol. 2017 Dec 1584(1):e02136-17.  

Chemical & Physical Properties

[ Molecular Formula ]:
C5H9NO

[ Molecular Weight ]:
99.13110

[ Exact Mass ]:
99.06840

[ PSA ]:
20.31000

[ LogP ]:
0.17650

Related Compounds