ANI-7
Names
[ CAS No. ]:
931417-26-4
[ Name ]:
ANI-7
Biological Activity
[Description]:
A potent and selective (up to 263-fold) inhibitor of breast cancer cells with GI50 of 0.5 uM (MCF-7), via activation the aryl hydrocarbon receptor (AhR) pathway; inhibits other cell lines derived from other tumour types with GI50 of 3.2-46 uM (lung, colon, ovary, neuronal, glial, prostate, and pancreas); potently inhibits the growth of T47D, ZR-75-1, MCF-7, SKBR3, and MDA-MB-468 breast cancer cells with GI50 of 0.16-0.38 uM, induces cell cycle arrest checkpoint activation and DNA damage; binds to the AhR, induces translocation to the nucleus, activates the XRE, induces CYP1 activity, culminating in cell cycle arrest, checkpoint activation, DNA damage and cell death.
[References]
References 1. Gilbert J, et al. Mol Pharmacol. 2017 Dec 21. pii: mol.117.109827. View Related Products by Target Aryl hydrocarbon Receptor (AhR)
Chemical & Physical Properties
[ Molecular Formula ]:
C13H8Cl2N2
[ Molecular Weight ]:
263.121