Phenyl benzoate

Names

[ CAS No. ]:
93-99-2

[ Name ]:
Phenyl benzoate

[Synonym ]:
Diphenylcarboxylate
Phenyl benzoate
Phenol,benzoate
MFCD00003072
Phenol, benzoate (7CI)
EINECS 202-293-2
benzenecarboxylic acid phenyl ester
Benzoic acid phenyl ester
Benzoic acid,phenyl ester
UNII-B8A3WVZ590
Benzoic acid, phenyl ester

Biological Activity

[Description]:

Phenyl benzoate is a benzoate ester obtained by the formal condensation of phenol with benzoic acid. Phenyl benzoate is a chloride transport blocker, inhibits Cl--dependent Glu accumulation into vesicles. Phenyl benzoate can be used as preservative in cosmetic products[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Chloride Channel

Research Areas >> Others

[In Vitro]

Phenyl benzoate (DPC) (0.1 μM-1 mM; 15 min) inhibits the Ca2+/Cl--dependent and -independent L-[3H]Glu (100 nM) binding to rat brain membranes[1].

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
314.0±11.0 °C at 760 mmHg

[ Melting Point ]:
68-70 °C(lit.)

[ Molecular Formula ]:
C₁₃H₁₀O₂

[ Molecular Weight ]:
198.217

[ Flash Point ]:
128.9±16.7 °C

[ Exact Mass ]:
198.068085

[ PSA ]:
26.30000

[ LogP ]:
3.59

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.585

[ Stability ]:
Stable. Incompatible with strong oxidizing agents, strong acids, strong bases.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DH6299500

CHEMICAL NAME :: Benzoic acid, phenyl ester

CAS REGISTRY NUMBER :: 93-99-2

BEILSTEIN REFERENCE NO. :: 1566346

LAST UPDATED :: 199712

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H10-O2

MOLECULAR WEIGHT :: 198.23

WISWESSER LINE NOTATION :: RVOR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1225 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 89,1179,1969

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R38

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DH6299500

[ HS Code ]:
2916310090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2916310090

[ Summary ]:
2916310090 other benzoic acid and its salts and esters。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

Articles

Pressurized liquid extraction-gas chromatography-mass spectrometry for confirming the photo-induced generation of dioxin-like derivatives and other cosmetic preservative photoproducts on artificial skin.

J. Chromatogr. A. 1440 , 37-44, (2016)

The stability and photochemical transformations of cosmetic preservatives in topical applications exposed to UV-light is a serious but poorly understood problem. In this study, a high throughput extra...

Discrimination of skin sensitizers from non-sensitizers by interleukin-1α and interleukin-6 production on cultured human keratinocytes.

J. Appl. Toxicol. 36 , 1129-36, (2016)

In vitro testing methods for classifying sensitizers could be valuable alternatives to in vivo sensitization testing using animal models, such as the murine local lymph node assay (LLNA) and the guine...

Chloride current activated by cyclic AMP and parathyroid hormone in rat osteoblasts.

Pflugers Arch. 415(1) , 104-14, (1989)

In primary cultures of rat osteoblasts, studied with the whole-cell configuration of the patch-clamp technique, 8-bromo-cyclic AMP (8BrcAMP) forskolin (FS) and 1-34 parathyroid hormone (PTH) were show...