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Amino-PEG10-amine

Names

[ CAS No. ]:
928292-69-7

[ Name ]:
Amino-PEG10-amine

[Synonym ]:
h2n-peg10-ch2ch2nh2

Biological Activity

[Description]:

Amino-PEG10-amine, a PEG-based PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[References]

[1]. Shan M, et al. Nonsteroidal bivalent estrogen ligands: an application of the bivalent concept to the estrogen receptor. ACS Chem Biol. 2013 Apr 19;8(4):707-15.

Chemical & Physical Properties

[ Density]:
1.082±0.06 g/cm3 (20 °C, 760 mmHg)

[ Boiling Point ]:
560.0±45.0 °C (760 mmHg)

[ Molecular Formula ]:
C22H48N2O10

[ Molecular Weight ]:
500.62400

[ Exact Mass ]:
500.33100

[ PSA ]:
144.34000

[ LogP ]:
0.47040

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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