PPARδ agonist 9

Names

[ Name ]:
PPARδ agonist 9

Biological Activity

[Description]:

PPARδ agonist 9 (compound 21) is a PPARδ agonist (EC50: 3.6 nM). PPARδ agonist 9 has in vivo efficacy, reducing serum levels of MCP-1 in mice and significantly inhibiting atherosclerosis progression in the LDLr-KO model (inhibition rate: 50-60%)[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR

Research Areas >> Metabolic Disease

[Target]

EC50:3.6 nM (PPARδ)[1]

[References]

[1]. Kato T, et al. Design, Synthesis, and Anti-Inflammatory Evaluation of a Novel PPARδ Agonist with a 4-(1-Pyrrolidinyl)piperidine Structure. J Med Chem. 2023 Aug 24;66(16):11428-11446..

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₈ClF₃N₄O₃S

[ Molecular Weight ]:
569.04