VRX-0466617

Names

[ Name ]:
VRX-0466617

[Synonym ]:
5-({4-[(4-bromophenyl)amino]phenyl}amino)-3-hydroxy-N-(1-hydroxypropan-2-yl)-1,2-thiazole-4-carboximidamide
4-Isothiazolecarboximidamide, 5-[[4-[(4-bromophenyl)amino]phenyl]amino]-2,3-dihydro-N-(2-hydroxy-1-methylethyl)-3-oxo-
5-({4-[(4-Bromophenyl)amino]phenyl}amino)-N-(1-hydroxy-2-propanyl)-3-oxo-2,3-dihydro-1,2-thiazole-4-carboximidamide

Biological Activity

[Description]:

VRX0466617, a selective Chk2 inhibitor, inhibits the phosphorylation of Chk2 Ser 19 and Ser33-35. VRX0466617 can be used in the study of cancer[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Checkpoint Kinase (Chk)

[References]

[1]. Carlessi L, et al. Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2. Mol Cancer Ther. 2007 Mar;6(3):935-44.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
545.4±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₀BrN₅O₂S

[ Molecular Weight ]:
462.36

[ Flash Point ]:
283.6±32.9 °C

[ Exact Mass ]:
461.052094

[ LogP ]:
3.06

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.714

[ Storage condition ]:
store at -20℃ for one year（Powder）

Related Compounds

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