1-(1,3-BENZODIOXOL-5-YL)-N-[5-[(S)-(2-CHLOROPHENYL)[(3R)-3-HYDROXY-1-PYRROLIDINYL]METHYL]-2-THIAZOLYL]-CYCLOPROPANECARBOXAMIDE

Names

[ Name ]:
1-(1,3-BENZODIOXOL-5-YL)-N-[5-[(S)-(2-CHLOROPHENYL)[(3R)-3-HYDROXY-1-PYRROLIDINYL]METHYL]-2-THIAZOLYL]-CYCLOPROPANECARBOXAMIDE

Biological Activity

[Description]:

VRT-534 targets connexin 26 (Cx26). Vrt-534 exhibits dose-responsive binding to recombinant WT Cx26 and mutant Cx26 K188N with EC50 value of 19 μM and 5 μM, respectively. Vrt-534 can be used in research related to hearing impairment[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[Target]

Cx26:19 μM (EC50)

[References]

[1]. Wang D, et al. A Chemical Chaperone Restores Connexin 26 Mutant Activity. ACS Pharmacol Transl Sci. 2023 Jun 1;6(7):997-1005.

Chemical & Physical Properties

[ Density]:
1.510±0.06 g/cm3 (20 °C, 760 mmHg)

[ Molecular Formula ]:
C₂₅H₂₄ClN₃O₄S

[ Molecular Weight ]:
497.99

[ Exact Mass ]:
497.11800

[ PSA ]:
112.16000

[ LogP ]:
4.36240

Related Compounds

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