UHRF1 PHD inhibitor MLD4
Names
[ CAS No. ]:
922067-76-3
[ Name ]:
UHRF1 PHD inhibitor MLD4
Biological Activity
[Description]:
UHRF1 PHD inhibitor MLD4 is a specific compound that selectively inhibits the UHRF1-histone interaction (IC50=12.4 uM), targets the PHD finger of UHRF1, specifically disrupting histone H3 arginine 2 interactions with the PHD finger.UHRF1 PHD inhibitor MLD4 inhibited binding between H3K9me3(FAM) and UHRF1 with IC50 of 24-26 uM, displace UHRF1-histone H3 binding in cells.
[References]
1. Wallace H Liu, et al. Biochemistry. 2022 Feb 10.
Chemical & Physical Properties
[ Molecular Formula ]:
C22H32N4O4
[ Molecular Weight ]:
416.522
Related Compounds
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.