2-Chlorophenothiazine
Names
[ CAS No. ]:
92-39-7
[ Name ]:
2-Chlorophenothiazine
[Synonym ]:
EINECS 202-152-5
10H-Phenothiazine, 2-chloro-
2-Chloro-10H-phenothiazine
MFCD00005016
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
395.7±31.0 °C at 760 mmHg
[ Melting Point ]:
195-200 °C(lit.)
[ Molecular Formula ]:
C12H8ClNS
[ Molecular Weight ]:
233.717
[ Flash Point ]:
193.1±24.8 °C
[ Exact Mass ]:
233.006592
[ PSA ]:
37.33000
[ LogP ]:
5.18
[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C
[ Index of Refraction ]:
1.680
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SN7580000
- CHEMICAL NAME :
- Phenothiazine, 2-chloro-
- CAS REGISTRY NUMBER :
- 92-39-7
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C12-H8-Cl-N-S
- MOLECULAR WEIGHT :
- 233.72
- WISWESSER LINE NOTATION :
- T C666 BM ISJ EG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 18 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Bacteria - Escherichia coli
- DOSE/DURATION :
- 160 mg/L
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 26,1205,1977
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36-S37/39
[ RIDADR ]:
UN 2811 6.1/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
SN7580000
[ Hazard Class ]:
6.1
[ HS Code ]:
2934300000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2934300000
[ Summary ]:
2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
J. Biol. Chem. 288(13) , 9153-64, (2013)
Glioblastoma multiforme (GBM), like most cancers, possesses a unique bioenergetic state of aerobic glycolysis known as the Warburg effect. Here, we documented that methylene blue (MB) reverses the War...
Broad specific enzyme-linked immunosorbent assay for determination of residual phenothiazine drugs in swine tissues.Anal. Biochem. 454 , 7-13, (2014)
In this study, a novel generic hapten of phenothiazine drugs was synthesized by derivatization of 2-chlorophenothiazine with sodium bromoacetate. Then the hapten was coupled to bovine serum albumin fo...
N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.J. Med. Chem. 54 , 4247-63, (2011)
A total of 53 N-benzoylated phenoxazines and phenothiazines, including their S-oxidized analogues, were synthesized and evaluated for antiproliferative activity, interaction with tubulin, and cell cyc...