Transdermal Peptide

Names

[ Name ]:
Transdermal Peptide

[Synonym ]:
Transdermal Peptide
L-Alanyl-L-cysteinyl-L-seryl-L-seryl-L-seryl-L-prolyl-L-seryl-L-lysyl-L-histidyl-L-cysteinylglycine

Biological Activity

[Description]:

Transdermal Peptide is a 11-amino acid peptide, binds to Na+/K+-ATPase beta-subunit (ATP1B1), and enhances the transdermal delivery of many macromolecules.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Peptides

Research Areas >> Others

[In Vitro]

Transdermal Peptide (TD1) binds to ATP1B1, and mainly interacts with the C-terminus of ATP1B1 in yeast and mammalian cells. The interaction affects the expression and localization of ATP1B1 and epidermal structure, but can be antagonized by the exogenous competitor ATP1B1 or be inhibited by ouabain. Inhibition of Transdermal Peptide binding to ATP1B1 causes decreased delivery of macromolecular drugs across the skin[1].

[References]

[1]. Wang C, et al. Role of the Na(+)/K(+)-ATPase beta-subunit in peptide-mediated transdermal drug delivery. Mol Pharm. 2015 Apr 6;12(4):1259-67.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.450±0.06 g/cm3

[ Molecular Formula ]:
C₄₀H₆₆N₁₄O₁₆S₂

[ Molecular Weight ]:
1063.17000

[ Exact Mass ]:
1062.42000

[ PSA ]:
558.75000

[ Water Solubility ]:
Very soluble (1000 g/L) (25 ºC)

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.