λ-Cyhalothrin

λ-Cyhalothrin is a high efficiency, broad-spectrum type II synthetic pyrethroid insecticide containing α-cyano group. λ-Cyhalothrin is used to control a wide range of pests in a variety of applications. λ-Cyhalothrin is a neurotoxin that targets sodium channels in the membranes of neurons in the central nervous system[1].

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Research Areas >> Endocrinology

Research Areas >> Infection

Research Areas >> Neurological Disease

The mechanism of λ-Cyhalothrin toxicity produces delay in sodium channel inactivation, which leads to persistent depolarization of the nerve membrane. λ-Cyhalothrin produces membrane depolarization, calcium ion infl ux, and neurotransmitter release from rat brain synaptosomes[1]. λ-Cyhalothrin possesses estrogenic properties and has an ability to function as a xenoestrogen promoting human breast carcinoma cell proliferation in vitro[1]. λ-Cyhalothrin has found multiple uses in pest (fleas, cockroaches, flies, and ants) control[1]. λ-Cyhalothrin is highly effective against the malaria transmitting species of Anopheles[1].

The effect of λ-Cyhalothrin (i.p.) on memory, movement activity, and co-ordination in mice exposed to bilateral clamping of the carotid arteries (BCCA) is investigated. Neither memory nor movement co-ordination are impaired by BCCA or λ-Cyhalothrin. Exploratory locomotor activity is significantly reduced in the BCCA/LCH group. Spontaneous movement activity is significantly reduced in the BCCA/λ-Cyhalothrin group . Exposure to λ-Cyhalothrin coexisting with BCCA decreases motor activity in the mice in 2 subsequent 30-min[1].

[1]. Barbara Nieradko-Iwanicka, et al. Effect of Lambda-Cyhalothrin on Memory and Movement in Mice After Transient Incomplete Cerebral Ischemia. Ann Agric Environ Med. 2011;18(1):41-5.

MOLECULAR FORMULA :

C23-H19-Cl-F3-N-O3

MOLECULAR WEIGHT :

449.88

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

56 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,203,1991

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

632 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,203,1991

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1951 ug/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :

PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971- Volume(issue)/page/year: 30,79,1988

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Bird - duck

DOSE/DURATION :

>3950 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C175,1991

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Mammal - species unspecified

DOSE/DURATION :

60 mg/m3/4H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,203,1991