7’-OH-N-trityl morpholinothymine

Names

[ Name ]:
7’-OH-N-trityl morpholinothymine

[Synonym ]:
7-hydroxy-N-trityl morpholinothymidine
2-hydroxymethyl-4-trityl-6-(thymin-1-yl)morpholine
1-((2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl)-5-methylpyrimidine-2,4-(1H,3H)-dione
7'-OH-N-trityl morpholino thymine

Biological Activity

[Description]:

7’-OH-N-trityl morpholinothymine (PMO Thymidine Precusor) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₂₉N₃O₄

[ Molecular Weight ]:
483.56

[ Exact Mass ]:
483.21600

[ PSA ]:
87.56000

[ LogP ]:
2.96670