Lu-aa47070

Names

[ Name ]:
Lu-aa47070

[Synonym ]:
phosphoric acid mono{2-[(E/Z)-4-(3,3-dimethylbutyrylamino)-3,5-difluorobenzoylimino]thiazol-3-ylmethyl} ester
phosphoric acid mono-{2-[(E/Z)-4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} ester
LU-AA47070

Biological Activity

[Description]:

Lu AA47070 is a phosphonooxymethylene prodrug of a potent and selective Adenosine A2A receptor antagonist. Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[In Vivo]

Lu AA47070 (3.75、7.5、15、30 mg/kg；腹腔注射) 逆转由亚慢性给药 D2 拮抗剂匹莫齐特（1.0 mg/kg；腹腔注射）引起的下颌颤动、僵直和运动抑制[2]< /sup>。 Animal Model: Male Sprague Dawley rats[2] Dosage: 3.75, 7.5, 15, 30 mg/kg Administration: I.p. Result: Reversed the tremulous jaw movements, catalepsy, and locomotor suppression induced by subchronic administration of the D2 antagonist pimozide (1.0 mg/kg IP).

[References]

[1]. Discovery of Phosphoric Acid Mono-{2-[(E/Z)-4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} Ester (Lu AA47070): A Phosphonooxymethylene Prodrug of a Potent and Selective hA2A Receptor AntagonistJ. Med. Chem., Article ASAPDOI: 10.1021/jm1008659Publication Date (Web): January 6, 2011

[2]. Collins LE, et al. The novel adenosine A2A antagonist Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade. Pharmacol Biochem Behav. 2012 Jan;100(3):498-505.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₂₀F₂N₃O₆PS

[ Molecular Weight ]:
463.39

[ Exact Mass ]:
463.07800

[ PSA ]:
168.27000

[ LogP ]:
3.08340

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.