LDN-75654

Names

[ Name ]:
LDN-75654

[Synonym ]:
3-Isoxazolecarboxamide, N-(3-chloro-4-fluorophenyl)-5-(1-methylethyl)-
N-(3-Chloro-4-fluorophenyl)-5-isopropyl-1,2-oxazole-3-carboxamide

Biological Activity

[Description]:

LDN-75654 is a novel potent SMN2 modulator (EC50=1.8 uM; Emax 186%), increases SMN protein in spinal cord and brain in mice.

[References]

References 1. Rietz A, et al. J Med Chem. 2017 Jun 8;60(11):4594-4610. View Related Products by Target SMN2 Modulator

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
327.9±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₂ClFN₂O₂

[ Molecular Weight ]:
282.698

[ Flash Point ]:
152.1±27.9 °C

[ Exact Mass ]:
282.057129

[ LogP ]:
3.51

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.582

Related Compounds

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