CHK1-IN-2

CHK1-IN-2 is a checkpoint kinase 1 (CHK1) inhibitor, with an IC50 of 6 nM.

Signaling Pathways >> Cell Cycle/DNA Damage >> Checkpoint Kinase (Chk)

Research Areas >> Cancer

Chk1:6 nM (IC50)

CHK1-IN-2 is a checkpoint kinase 1 (CHK1) inhibitor, with an IC50 of 6 nM, which is a potential cancer therapeutic that can be utilized for enhancing the efficacy of DNA damaging agents[1].

[1]. Yang B, et al. Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors. J Med Chem. 2018 Feb 8;61(3):1061-1073.

LY2606368 | AZD7762 | CCT245737 | LY2603618 | CCT241533 hydrochloride | MK-8776(SCH 900776) | CHIR-124 | CHK2 INHIBITOR II | PF-477736 | CCT244747 | GDC-0575(ARRY-575) | CHK-IN-1 | CHK1 inhibitor