EC 144

Names

[ Name ]:
EC 144

[Synonym ]:
5-[2-Amino-4-chloro-7-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-2-methyl-4-pentyn-2-ol

Biological Activity

[Description]:

EC144 is a potent and selective inhibitor of heat shock protein 90 (Hsp90) with an IC50 of 1.1 nM. EC144 inhibits tumor growth and causes partial tumor regressions. EC144 has the potential for the research of cancer diseases[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> HSP

Signaling Pathways >> Cell Cycle/DNA Damage >> HSP

[References]

[1]. Shi J, et al. EC144 is a potent inhibitor of the heat shock protein 90. J Med Chem. 2012;55(17):7786-7795.

Chemical & Physical Properties

[ Density]:
1.29±0.1 g/cm3(20 °C , 760mmHg)

[ Boiling Point ]:
674.1±65.0 °C (760 mmHg)

[ Molecular Formula ]:
C₂₁H₂₄ClN₅O₂

[ Molecular Weight ]:
413.90100

[ Exact Mass ]:
413.16200

[ PSA ]:
99.08000

[ LogP ]:
3.82930

Related Compounds

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